PREPARATION AND EVALUATION OF HEMOLYTIC ACTIVITY OF COMPOSITES BASED ON NATURAL DIATOMITE AND UREA CONTAINING HETEROCYCLIC COMPOUND

In this study, new composite materials based on a porous inorganic compound - diatomite - were developed for the first time by modifying its surface with a promising macromolecular compound - bamboo[6]uril. The materials were obtained by applying bambus[6]uril diatomite, which is in the form of a dispersion in water, to the surface. The materials were characterized using IR spectroscopy and SEM, and their hemolytic effect was determined. The results showed that materials containing bambus[6]uril on the surface did not exhibit their own antibacterial and hemolytic effects, which provides a reliable basis for their use as biocompatible materials. The results obtained are a promising alternative for the creation of stable and effective biocomposites, allowing in the future to implement supramolecular strategies involving encapsulated bambusurils in such processes.